Effect of Aqueous Extract  Artemisia herba alba  Plant on Some Histological Parameters of Some Organs in the male Rats Induced Diabetes

	Effect of Aqueous Extract Artemisia herba alba Plant on Some Histological Parameters of Some Organs in the male Rats Induced Diabetes
journal of kerbala university
Article 1, Volume 11, Issue 2, 2015, Pages 19-32 PDF (0 K)
Abstract
The present study was conduct to investigate the histological effects of aqueous extract of Artemisia herba alba .seventy five male rats were randomly divided to five groups ( 15 animals per group ) the first group (G1) was received physiological normal salin orally for two months and set as negative control group ,Diabetes was induced in all animals of other four groups by intraperitoneal injection 150 mg / kg of body weight of aloxan ,however the second grops( G2) set as positive control while the third , fourth and fifh groups were received 500 , 1000 and 1500 mg/kg of body weight of aqueous extractof Artemisia herba alba orally after one month of induction diabetes respectively ,Rate were sacrificed and liver ,kidney and heart were dissect out in order to study histological changes. The results of the study showed that the development of diabetes in male rat caused obtain changes in the liver of infected animals compared with the healthy control group, As observed in multiple regions of the hepatic lobules infiltration of inflammatory cells vaculation in hepatic cells with expansion and irregular sinusiods compared with the negative control group, the groups that treatment with aqueous extract of Artemisia herba alba showed protective effect of the liver with activation of Kupffers cell While the development of diabetes in male rat caused changes in the Kidney of infected animals compared with the control group, as shown by the atrophy of the size of the glomerulus with clear expansion in the low bed Bowman also the presence of the protein deposited materials in the renal tubules. aqueous extract of Artemisia herba alba showed protective effect on the Kidney through the reduction of degenerative changes and glomerulus-size close to normal. As also showed the group treatment aqueous extract of Artemisia herba alba dose of 1000,1500 mg / kg changes histology includ atrophy of the size of the glomerulus with the expansion of the Bowman's capsule. The results of the study , showed significant changes in heart tissue of infected animals and the treatment with aqueous extract of Artemisia herba alba plant .

Statistics Article View: 85 PDF Download: 32