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Efficiency effect of the chamomile extracts Matricaria chamomile which biofertized with the Bacillus subtilis and Pseudomonas fluorescens of mice blood clotting properties | ||
| journal of kerbala university | ||
| Article 1, Volume 11, Issue 4, 2015, Pages 61-69 PDF (0 K) | ||
| Abstract | ||
| This study was conducted at the medical plants farm , and the animal house of the College of Pharmacy / Kerbala University . The aim was to investigate effects of biofertilization with Bacillus subtilis , Pseudomonas fluorescens and Bacillus subtilis + Pseudomonas fluorescens on the composition of active ingredient (Anti-coagulant) using Matricaria chamomile alcoholic flower extracts , it is also aimed to asses the effects of the extrast on some blood clotting features. The primary diagnostic results revealed that M. chamomile flower alcoholic extracts for all biofertilization treatments contain phenols , alkaloids , terpens , and glycosides. The Lethal dose fifty (LD50) of alchol extract was 9875 mg / kg by subcutaneous injection. Results showed that there was a highly significant increasing in the clotting of blood. The interaction between (B. + Ps.) alcoholic extract and dose 1250 mg / kg produced an increase in bleeding time , clotting time prothrombine time , and thromboplastin time as (9.01) minutes , (8.99) minutes , (23.09) second and (43.63) second , compared to control groups . These values were (2.89) minutes , (2.66) minutes , (11.31) second , (20.73) second for all above parameter respectively. The high concentration of M. chamomile (1000 , 1250) mg / kg caused and infiltration in the congestion region in the orgaus , kidney , and liver section. The present study appeared that the lowest dose of the blood anticoagulant to alcoholic extracts for (B. Ps.) treatment was 25 mg/kg of the blood , and it works a similarly to heparin. | ||
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