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COLORIMETRIC ASSAY OF ASPIRIN USING MODIFIED METHOD | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 12, Issue 3, 2009, Pages 1-7 | ||
| Authors | ||
| Amera Abbas; May Mohammed Jawad Al-Mudhafar; Maadh Qusay Abdulkadir | ||
| Abstract | ||
| AbstractIn this research, we did this qualitative and quantitative study in order to improve the assay ofaspirin colorimetrically using visible spectrophotometer. This method depends on aqueoushydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violetcolored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximumabsorption at 530nm. This procedure was applied to determine the purity of aspirin powder andtablet. The results were approximately comparative so that the linearity was observed in the highvalue of both correlation coefficient (R = 0.998) and Determination Coefficient or Linearity (R2 =0.996) while the molar absorpitivity was 1.3´103 mole-1.L.cm-1. This improvement cancelled theacid or base aided hydrolysis which is widely used during aspirin assay. This method could be alsoapplied to salicylic acid. | ||
| Keywords | ||
| ferric chloride; hydrolysis; absorbance | ||
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