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THE EFFECT OF MITOMYCIN C ON SOME IMMUNOLOGICAL AND CYTOGENETICAL PARAMETERS IN ALBINO MALE MICE | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 12, Issue 3, 2009, Pages 129-132 | ||
| Author | ||
| Lamees Kh. I. Al-Dahiri | ||
| Abstract | ||
| AbstractThe present study was carried out to shed light on the effect of Mitomycin C onsome immunological and cytogenetical parameters in albino male mice. The effects of the drugswere investigated after one day treatment with a single dose(0.005 mg/ml). All treatments wereparalleled by controls. The results revaled that the dose of MMC significantly decreased thetotal count of leucocytes, lymphocytes and neutrophils, while the monocytes and eosinophilsshowed no significant differences, as compared to controls.Such observation was positivelycorrelated with the phagocytic index and plague forming cells. Moreover, the mitotic index showedsignificantly decreased, as compared with controls. In contrast, the spontaneous formation ofmicronuclei and chromosomal aberration in the bone marrow cell was significantlyincreased. The results showed that the MMC had immune suppressive effect. Also, the genotoxicand mutgenic effects was observed | ||
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