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SYNTHESIS OF SOME NEW N-SUBSTITUTED-1,2,3,4-TETRAHYDROCARBAZOLE DERIVATIVES AND STUDY THEIR BIOLOGICALACTIVITY | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 13, Issue 1, 2010, Pages 26-35 | ||
| Authors | ||
| ; M.N. Al-Quaz; Suaad M.H. Al-Majidi | ||
| Abstract | ||
| The aim of this research synthesis compounds different heterocyclic new rings, sulfur and nitrogen containing in structures, substituted-N-(1,2,3,4-tetrahydrocarbazol) [THCz], through the prepared a-chloro-N-tetrahydocarbazol acetamide [2] which was prepared two ways. The first method by condensation [THCz] with chloro acetyl chloride in the presence of triethylamine and dry benzene as solvent. The second method the prepared [THCz]2Hg [1], then condensation with chloroacety chloride in DMSO. Which was treated hydrazinehydrate to give a-hydrazine-Ntetrahydrocabazol acetamide [3]. The hydrazine derivative [3] with five acid anhydrids [Maleic, Phthalic, Succinic, Glutaric and Citraconic] to produce novel diazine which contain the acid refered above on substituted-N-tetrahydrocarbazol acetamide [4a-e] respectively. The compound [2] was treated with each of urea and thiourea to give compounds [5,6] respectively. Followed the cyclization of compounds [5,6] by used p-phenylphencylbromide gave oxazol [7] and thiazol [8] on substituted-N-tetrahydrocarbazol acetamide, furthermore, new Schiff base [9a-e] were prepared through the reaction of the hydrazine derivative [3] with aromatic aldehydes. The prepared compounds identified by spectral methods [UV, FTIR, H-NMR, 13 CNMR] and measurement some of its physical properties and some specific reaction, furthermore we were studied the effects of the preparing on some strains of bacteria. | ||
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