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Anti-Liver membrane Antibody predict outcome of Autoimmune Hepatitis | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 50, Issue 3, 2008, Pages 395-399 | ||
| Authors | ||
| Akram A. Najeeb; Batool A. Al-Haidary; Eman Sh. AL- Obeidy | ||
| Abstract | ||
| Background: Autoantibodies against liver membrane are the specific autoantibodies found in AIH. Cytochrome P450 1A2 has been identified as the target autoantigen for these autoantibodies The aim of the study : is to evaluate the prevalence and clinical relevance of LMA in AIH Methods: The study was performed on 73 Iraqi patients with chronic active hepatitis (CAH) of unknown cause , attending the teaching hospital for gastroenterology and liver disease in a period between November 2003 and July 2004. Anti-liver membrane antibodies were studied by IFA technique. Results: LMA was detected in the sera of 28(57.14)and 3(37.5%) patients with type 1 and type 3 AIH respectively, but never in the sera of healthy group . Conclusion: It was concluded that LMA is present in type-1 and type-3 AIH but not in sera of patients with type-2 or in healthy control group. | ||
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