- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
BATCH AND FLOW INJECTION SPECTROPHOTOMETRIC METHODSFOR DETERMINATION OF PARACETAMOL IN PHARMACEUTICALPREPARATIONS VIA OXIDATIVE COUPLING WITH4-AMINOANTIPYRINE | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 13, Issue 1, 2010, Pages 11-19 | ||
| Authors | ||
| Zaineb Falah; Raghad Sinan; Mouayed Q. Al-Abachi | ||
| Abstract | ||
| A simple, rapid and sensitive batch and flow injection spectrophotometric methods have been developed for the determination of paracetamol in pure form and pharmaceutical preparations. The proposed methods are based on the oxidative coupling reaction of paracetamol with 4-aminoantipyrine in presence of ammonium persulfate in alkaline medium to produce an orangereddish product that having absorptivity maximum at 461 nm. The optimum reaction conditions and other analytical parameters have been evaluated. Linearity was observed from 2-16 and 100-700 g mL -1 paracetamol by batch and flow injection procedures, respectively. Statistical analysis of the results and comparison with results by the British Pharmacopoeia method are also reported. | ||
| Keywords | ||
| paracetamol; Spectrophotometric; Flow Injection; Aminoantipyrine; oxidative coupling reaction | ||
|
Statistics Article View: 185 PDF Download: 6 |
||