Study The Predictive Value Of Troponin –I And Histopathological Changes During Acute And Chronic Myocardial Infarction In Adult Male Rats.

Haider Hammadi, Mahdi

	Study The Predictive Value Of Troponin –I And Histopathological Changes During Acute And Chronic Myocardial Infarction In Adult Male Rats.
Al-Mustansiriyah Journal of Science
Article 1, Volume 26, Issue 2, 2015, Pages 13-17
Author
Mahdi Haider Hammadi
Abstract
Our study used cryo-injury model to induce myocardial infarction in adult male rats by using liquid nitrogen (-196 co)and investigate the physiological changes during acute and chronic M.I through checking serum blood biomarker (Troponin-I), and doing scoring between the biomarker and the histopathological changes in rats myocardium in different period time We used a total of 35 adult male rats and divided them in to subgroups as following: • Fifteen rats for induced acute myocardial infarction (4/hr., 8/hr. 24/hr.). • Fifteen rats for induced chronic myocardial infarction (7/days, 14/days, 28/days). • Five rats as a control healthy group. Troponin-I increased significantly at 4 hours post experimental induction of myocardial infarction and persist significantly high for 7 days then decline later on. The histopathological changes during acute and chronic M.I reflect the physiological changes in concentration of cardiac biomarker (CTnI). On this results showed highly significant(P<0.01) increase in concentration levels of serum CTnI at 4/hr. post experimental induction of M.I this results means the importance of CTnI as highly specific and sensitive marker of myocardial necrosis ; and The histopathological changes during acute and chronic M.I it is close related with physiological changes occur in cardiac biomarker concentration and appear early in blood

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