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Spectrophotometric Determination of Carbamazepine Via Oxidative Coupling Reaction with 2,4-dinitrophenyl hydrazine | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 29, Issue 1, 2016, Pages 226-238 | ||
| Authors | ||
| Sahar R. Fadhel; Najwa I. Abdulla; Intidhar D. Sulaiman | ||
| Abstract | ||
| An accurate and sensitive spectrophotometric method has been developed for the determination of carbamazepine (CRN.) in pure and dosage forms. The method is based on the oxidation of 2,4-dinitrophenylhydrazine (2,4-DNPHz) by potassium periodate than coupling with carbamazepine (CRN.) in alkaline medium to form a stable yellowish brown colored water-soluble dye with a maximum absorption at 485 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (4-50 μg.mL-1) with molar absorptivity of (6.7335×103 L.mol-1.cm-1). The limit of detection was (0.1052 μg.mL-1) and Sandell’s sensitivity value was 0.0350 μg.cm-2.The proposed method has been applied successfully to the determination of carbamazepine in pharmaceutical preparation. | ||
| Keywords | ||
| Spectrophotometric; Carbamazepine; dinitrophenyl hydrazine; Dosage forms; Oxidative Coupling | ||
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