Study the preventive effect   of aqueous extract of Gingko biloba on cerebral damage induced by ischemia/reperfusion in rat

T. Mohammed, Mustafa

	Study the preventive effect of aqueous extract of Gingko biloba on cerebral damage induced by ischemia/reperfusion in rat
Journal of the Faculty of Medicine
Article 1, Volume 58, Issue 2, 2016, Pages 183-186
Author
Mustafa T. Mohammed
Abstract
Abstract: Background: Background: cerebral damage may occur in a variety of clinical settings and this remains a significant problem. Therefore, it seems possible that the administration aqueous extract of Gingko biloba might protect the brain against the ischemia reperfusion injury. Objectives: The study included knowledge Phytochemical Composition and determine whether Gingko biloba in the aqueous extract prevents or decreases I/R brain damage. Methods: Thirty rats were divided into three groups as control, I/R group and Gingko biloba treatment group. Serum was used for the estimation of biochemical parameters: oxidative stress levels of nitric oxide (NO) and lipid peroxida¬tion (LPO) and blood was used for the estimation of enzyme immunoassay: Interleukin-8 (IL-8), tumor necrosis factor Alpha (TNF-α), interleukin-1β (IL-1β). Results: The results showed that the extract contain : glycosides , saponins ,tannins ,phenolic compounds , resins, flavonoids ,alkaloids and proteins.The levels of Oxidative stress in group 3 were significantly lower than those in group 2 as well as the levels of enzyme immunoassay in group 3 were significantly lower than those in group 2. Conclusion: The present results suggest that Gingko biloba treatment protects the rat brain against ischemia-reperfusion brain damage. Key words: Gingko biloba, preventive effect , ischemia/reperfusion , brain damage
Keywords
Gingko biloba; preventive effect; ischemia; brain damage

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