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Synthesis, Characterization and Microbial Study Via Some New Salbutamol'sDerivatives | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 14, Issue 1, 2011, Pages 50-57 | ||
| Authors | ||
| Sanaa A. Al-Sahib; Saadiyah A. Dhahir; Abdel-Amir M. Fenjan | ||
| Abstract | ||
| During this work, some new medical salbutamol,s derivatives were prepared, characterized andtheir biological activity was determined. A simple and efficient procedure for obtaining 4-(1-oxoacetyl-2-tert-butylaminoethyl)-6-methanolyl phenol 2 (acetylated salbutamol 2) from a reactionbetween acetic anhydride and 4-(1-hydroxy-2-tert-butylaminoethyl)-6-methanolyl phenol 1(salbutamol 1) in an acidic medium was reported. A coupling reaction between the diazonium saltsof aniline derivatives with an acetylated salbutamol 2 gave the new corresponding azo derivativesin the selective yields. These compounds were characterized by various physical techniques like:FTIR spectra, UV-Visible spectra, determination of the total number of hydroxyl groups of anacetylated salbutamol 2, melting point and the evaluation of microbial activity in vitro against Gram+Ve, Gram -Ve bacteria and fungi. A potent antibacterial activity was noticed only for the followingcompounds:2-(2¢,4¢-Dichloroazophenyl)-4-(1-oxoacetyl-2¢¢-tert-butylaminoethyl)-6-methanolyl phenol 3.2-(2¢,3-Dimethylazophenyl)-4-(1-oxoacetyl-2¢¢-tert-butylaminoethyl)-6-methanolyl phenol 5.2-(5-Mercapto-1¢,3,4¢-thiadiazol-2¢-azoyl)-4-(1-oxoacetyl-2¢¢-tert-butylaminoethyl)-6-methanolylphenol 6. | ||
| Keywords | ||
| Acetylated salbutamol; aniline derivatives; diazonium salt and microbial study | ||
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