STUDUY THE ROLE OF QUERCETIN IN EMULATION THE SIDE EFFECTS OF ANTICANCER DRUG DOXORUBICIN IN ELECTRICAL ACTIVITY OF THE HEART IN MALE LOCAL RABBITS.

K. Wali, Jameel

	STUDUY THE ROLE OF QUERCETIN IN EMULATION THE SIDE EFFECTS OF ANTICANCER DRUG DOXORUBICIN IN ELECTRICAL ACTIVITY OF THE HEART IN MALE LOCAL RABBITS.
Euphrates Journal of Agriculture Science
Article 1, Volume 8, Issue 2, 2016, Pages 113-122
Author
Jameel K. Wali
Abstract
The aim of this study was to detect the treatment effect of Quercetin in emulation the toxic effect of Doxorubicin drug in heart function in 32 locale male rabbits divided randomly into four groups treated for 28 days as follow: control group orally given distal water daily and injected with 4ml normal saline weekly, first treatment group given orally 10mg/kg Quercetin daily and injected with 4ml normal saline weekly, Second treatment group injected with 4mg/kg doxorubicin weekly and given orally distal water daily, while third treatment group given 10mg/kg Quercetin daily and injected with 4mg/kg doxorubicin weekly. The results showedthere is significant decrease(P<0.05)in sodium level in the second group treatedwith doxorubicin in compared with control, first and third groups, conversely first and second groups shows no significant difference (P>0.05) compared with control group. The results of potassium and calcium showed there is significant increase (P<0.05)in second group compared with control group and first group, while ions levels significantly decreased ((P<0.05)in the third group compared with second group and closed to the normal range in control and first groups. The results of electrocardiogram showed there is no significant deference (P>0.05) in P, Q, R waves amplitude among all the groups of the experiment. Treated the animals in second group with Doxorubicin caused significantlyincrease (P<0.05) in T wave amplitude compared with control, first and third groups, as well as doxorubicin injection in the second group caused significant prolongation (P<0.05) T, QT and ST intervals compared with the rest groups of the experiment.The results showed there is no significant deference (P>0.05) in T wave and QT and ST intervals in all groups which treated with Quercetin (Firs and third ) compared with the control group. As result of that we suggest that Quercetin has very important role in the maintains on the normal electrocardiogram and the normal level of ions related with electrocardiogram.
Keywords
Electrocardiogram; cancer; Doxorubicin; Quercetin

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