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Biological Activity of Thiazole Derivatives on SomePathogenic Microorganisms | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 14, Issue 1, 2011, Pages 1-6 | ||
| Authors | ||
| Shayma M. Ahmad; Zahraa. S. Saeed; Firas A. Hassan | ||
| Abstract | ||
| The thiazole derivatives were prepared by the reaction of benzaldehyde derivatives with(2-thiooxamide-5-(p-bromobenzene)-1,3-thiazole) that was readily prepared by heatingdithiooxamide with 4-bromophenacylbromide. Within invitro study the the effect of the preparedcompounds on the growth of two types of fungi geotrichum cadidum and Trichophyton rubrum andthe bacteria Escherichia coli, pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiellapneumoniae was evaluated. Incubation time and concentration were studied to find the optimalconditions for the activity. Compound II with the concentration 20 mg/ml found to be the mostactive compound toward geotrichum and Trichophyton rubrum. Statistical analysis of the values ofcolonial diameter shows low percentage error for the studied fungi with regard to incubation time. | ||
| Keywords | ||
| Thiazole derivatives; antibacterial activity; antifungal activity; Statistical analysis | ||
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