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Synthesis of 1-Nonyl-4-[(6-Deoxy-1,2:3,4-Di-O-Isopropylidene-α-D-Galactos-6-yl)oxymethyl]1H-1,2,3-Triazole Via Click Chemistry | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 14, Issue 1, 2011, Pages 58-67 | ||
| Author | ||
| Rasha Saad Jwad | ||
| Abstract | ||
| The SN2 reaction of nonyl bromide with sodium azide in DMF afforded Nonyl azide (1).Dgalactosehas been protected by acetone in acidic medium gave 1,2:3,4-di-O-isopropylidene-α-Dgalactose(2). Williamson etherfication of (2) with propargyl bromide and sodium hydroxideyielded 6-O-(2-Propynyl)-1,2:3,4-di-O-isopropylidene-α-D-galactose(3). [2+3] Cycloaddition of (3)to nonyl azide using Click conditions afforded1-Nonyl-4-[(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactose-6-yl)oxymethyl]1H-1,2,3-triazole(4). All prepared compounds have been characterizedby FT-IR ,1H NMR and 13CNMR. | ||
| Keywords | ||
| Triazoles; click chemistry; isopropylidene; galactose | ||
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