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Synthesis, Characterization, Theoretical Crystal Structure and Antibacterial Activities of Some Transition Metal Complexes of The Thiosemicarbazone (Z)-2-(Pyrrolidin-2-Ylidene)Hydrazinecarbothioamide | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 14, Issue 1, 2011, Pages 7-14 | ||
| Authors | ||
| Hazim Abdul Razzaq; Yasmien K. Al-Majedy; Ahmed A. H. Al-Amiery | ||
| Abstract | ||
| Problem statement: In Iraq like most third world countries, attempts to discovered a new antibioticdrugs derived from thiosemcarbazied and its metal complexes moreover develop the branch ofapplied in organic chemistry.Approach: New (Z)-2-(pyrrolidin-2-ylidene) hydrazinecarbo thioamide (L) was synthesized in agood yield by the reaction of pyrrolidone with thiosemicarbazide. Co(II), Ni(II), and Cu(II)complexes of (L) were prepared, and characterized by FT-IR, UV/visible spectra, 1HNR, and CHNanalysis moreover charge, bond length, bond angle, twist angle, heat of formation and steric energywere calculate by using of ChemOffice program. The free ligand and its metal complexes weretested in vitro against a number of microorganisms (Staphylococcus aurous, E.coli, Proteusvulgaris, Pseudomonas, and Klebsiella) in order to assess their antimicrobial properties.Results: The study indicates that these complexes have octahedral geometry, in addition it havehigh activity against tested bacteria.Conclusion/Recommendations: Based on the reported results, it may be concluded that ligand actas bidentate uninegative ligand, coordinating through one of the nitrogen atom and the sulfur atoms. | ||
| Keywords | ||
| Thiosemicarbazone; hydrazinecarbothioamide; antibacterial activity | ||
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