- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Amygdalin and magnetic water ameliorate histological changes in liver induced by 1, 2 dimethyl hydrazine | ||
| The Iraqi Journal of Veterinary Medicine (IJVM) | ||
| Article 22, Volume 40, Issue 1, 2016, Pages 136-139 PDF (0 K) | ||
| Authors | ||
| Ahmed S. Farhan; A. A. Thaker; Fadel M. Abed | ||
| Abstract | ||
| This study aimed at evaluating the ameliorative effect of amygdalin and magnetic water on 1,2-dimethyl hydrazine induced toxic damage in tissues and oxidative stress in rat liver. Seven groups of ten rats each were selected for the study. Group I animals were treated as control. Group II rats received 1,2-dimethyl hydrazine (20 mg/kg body weight) injections subcutaneously once a week for 16 consecutive weeks and then kept without any treatment untill the end of the experimental period. Group III rats received amygdalin (20 mg/100 mg) daily via Oro-gastric tube. Groups IV rats were given magnetic water freely. Group V rats were given 1,2-dimethyl hydrazine + amygdalin. Group VI rat were given 1,2-dimethyl hydrazine + magnetic water Group VII rats were given 1,2-dimethyl hydrazine + amygdalin + magnetic water. Liver histological changes were studied. Degenerative changes were observed in different areas of liver tissue in 1,2-dimethyl hydrazine group, and these changes include: Fibrosis with the appearance of cell necrosis, hemorrhage, fatty infiltration and pleomorphic nuclei. While other groups showed normal appearance of the hepatic cells but some changes were observed in 1,2-dimethyl hydrazine + amygdalin + magnetic water group include: Fibrosis with the appearance of cell necrosis, hemorrhage, fatty infiltration and pleomorphic nuclei but changes in this group were less than in 1,2-dimethyl hydrazine group. In conclusion, the present results suggest that the amygdalin and magnetic water have the potential to ameliorate carcinogen 1,2-dimethyl hydrazine induced hepatotoxicity by antioxidant and antiinflammation activity | ||
| Keywords | ||
| Amygdalin; Magnetic water; Dimethyl hydrazine; Rat liver | ||
|
Statistics Article View: 71 PDF Download: 46 |
||