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Immunophenotyic pro le of adult acute tic leukaemia in Iraq, a one year experience | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 8, Issue 2, 2015, Pages 164-169 | ||
| Authors | ||
| Ikball M. Hajem; Yasaamin A. Al-Amiri; Zakaa N. Al-Nidawy; Israa M. Al-Bayaa | ||
| Abstract | ||
| Background: Acute lymphoblastic leukaemia accounts for approximately 14% of leukaemia cases in the adults with B linage subtype being more common than T linage subtype. immnophenotyping using the multicolour ow cytometry is an essential tool for diagnosis, classi cation as well as treatment guidance and prognosis. Objectives: This study aims to provide an overview of the immunophenotypic pro le of adult ALL cases in Iraq, it’s possible link with other characters and also study the frequency of expression of aberrant myeloid antigens in them. Patients and methods: this is a descriptive study included 64 adult patients diagnosed as ALL in haematology unit at Bagh- dad teaching hospital for the period between May 2014 till May 2015 , immunophenotyping was carried out at the ow cytometry laboratory in the nursing home hospital using 6 coloured (BD-FACS-Canto II System from Becton Dickenson). Results: of the study population 63.7% of the cases were B-ALL and 27.5% were T-ALL, there was no signi cant difference in respect to age and gender between them. Of the CD markers used both CD10 and CD34 were signi cantly associated with B-ALL compared to T-ALL (p values 0.002 and 0.003 respectively).aberrant myeloid Ag expression was seen in 43.18% of B-ALL cases and in 52.6% of T-ALL cases with no signi cant difference however aberrant myeloid Ag expression was sig- ni cantly associated with CD34 expression with a p value of 00.018. Conclusion: Immunophenotyping retains a crucial place in the work up for patients with acute lymphoblastic leukaemia. CD34 was signi cantly associated with B linage ALL and with aberrant myeloid Ag expression, larger study with clinical evaluation and cytogenetic study is recommended to evaluate the impact of those ndings over prognosis. | ||
| Keywords | ||
| immunophenotying; ALL; multichannel ow cytometry; aberrant myeloid Ag expression | ||
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