Synthesis and Biological Studies of Co(II),Ni(II),Cu(II) and Zn(II)Complexes with New Compound N-[(2,3-dioxoindolin-1-yl)-N-methylbenzamide]

I.Omran, Rana; R.Abdulmageed, Zahraa; J.Jarad, Amer; M.Dedan, Ruaa; A.Mahmood, Muhanned; H.Alkam, Heam

	Synthesis and Biological Studies of Co(II),Ni(II),Cu(II) and Zn(II)Complexes with New Compound N-[(2,3-dioxoindolin-1-yl)-N-methylbenzamide]
Diyala Journal For Pure Science
Article 1, Volume 11, Issue 3, 2015, Pages 86-99
Authors
Rana I.Omran; Zahraa R.Abdulmageed; Amer J.Jarad; Ruaa M.Dedan; Muhanned A.Mahmood; Heam H.Alkam
Abstract
The N-[(2,3-dioxoindolin-1-yl)-N-methylbenzamide] was prepared by the reaction of acetanilide with isatin then in presence of added paraformaldehyde, the prepared ligand was identified by microelemental analysis, FT.IR and UV-Vis spectroscopic techniques. Treatment of the prepared ligand with the following selected metal ions (CoII, NiII, CuII and ZnII) in aqueous ethanol with a 1:2 M:L ratio, yielded a series of complexes of the general formula [M(L)2Cl2]. The prepared complexes were characterized using flame atomic absorption, (C.H.N) analysis, FT.IR and UV-Vis spectroscopic methods as well as magnetic susceptibility and conductivity measurements. Chloride ion content was also evaluated by (Mohr method). From the obtained data the octahedral structure was suggested for all prepared complexes. In addition biological activity of the ligand and complexes against three selected type of bacteria were also examined. Some of the complexes exhibit good bacterial activities.
Keywords
Mannich base; biological activity; Spectral studies

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