Extraction of Chitin and Chitosan from Shrimp Shell and loaded with drugs

Ali.S.Mahmood,; Ali.Taha.Ali,

	Extraction of Chitin and Chitosan from Shrimp Shell and loaded with drugs
Diyala Journal For Pure Science
Article 1, Volume 11, Issue 3, 2015, Pages 96-113
Authors
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Abstract
The study involves the grafting of some drug brought from the General Company for pharmaceutical Industries Samarra,Iraq (Furosemide) on natural Polymers derived from Shrimp Shells. The study includes several steps:First: Cleaning and grinding of the Shrimps Shells then extraction of natural Polymers of Chitin and Chitosan using 10% hydrochloric acid and 50% Sodium hydroxide.Second: Chemical grafting of the used Drugs on Chitin and Chitosan where carried..For Drugs Furosemide, They were loaded on Chitosan using glutraldehyde between the Drug and the Polymer to form the loaded drugs on Polymer.Third: The drugs ,polymers and loaded Polymers with drugs have been investigated by means of (FTIR- Spectroscopy ,UV-visible , and CHN analsis).Analysis in formation sugyest that the druge are successfully loaded on chitin and chitosan. Fourth: Studying of the slow liberation of Drugs from the Polymers by the use of Ultraviolat light at Room temperature. Fifth: study the effect of different pH on the rate of drug release from the network ,which showed that different pH values i.e pH(1.2, 7.2, 9.4) have Significant effect on the rate of release of the the drug from the loaded polymer chitosan showed highest release at the studied ( pH, i.e 1.2).
Keywords
Extraction of Chitin and Chitosan; Loading drugs on the natural polymers

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