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Synthesis of-3-(tert-butyldimethylsilyoxy)-4-Isopropylcyclopentanone (4) | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 12, Issue 2, 2016, Pages 28-40 | ||
| Author | ||
| Luma Salman Abd | ||
| Abstract | ||
| In this research the preparation of target compound was completed in three sequential steps. Starting from furfural alcohol (1) that was converted to racemic 4-hydroxycyclopent-2-enone (2) in 39% yield after treated with catalytic amount of KH2PO4 in water as a solvent. Protection of the free hydroxyl group in (2) with t-butyldimethylsilyl chloride in the presence of DMAP was the next step to furnish compound (3) in yield of 50%. Organocuprate conjugate addition on (3) provide compound (4) in yield of 50%. | ||
| Keywords | ||
| furfural alcohol; isopropyl group; dimethyl amine pyridine; conjugated addition | ||
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