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Synthesis of Some New Barbiturate Derivatives Via Schiff Bases | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 12, Issue 2, 2016, Pages 110-126 | ||
| Author | ||
| Ahlam J. Zaier | ||
| Abstract | ||
| A stable Schiff bases were prepared by condensation reaction between equimolar quantities of aromatic aldehydes with aromatic amines. Aromatic Schiff bases were undergo nucleophilic addition with acetyl chloride to give N-(chloro(phenyl)methyl)-N-phenylacetamides. The reaction of latter with diethylmalonate in basic medium yeild diethyl-2-(phenyl(N-phenylacetamido)methyl)malonates. The latter condense with urea in basic medium to give derivatives of barbiturate which used in the medical field as hypnotics. The prepared compounds were identified by FT.IR and UV-Vis spectroscopy. | ||
| Keywords | ||
| Schiff Base; Acetamide; Barbiturate; Pyrimidine | ||
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