Treatment of hyperhomocysteinemia and pregnancy outcome in patients with recurrent miscarriage

H. Humadi, Esraa

	Treatment of hyperhomocysteinemia and pregnancy outcome in patients with recurrent miscarriage
Mustansiriya Medical Journal
Article 1, Volume 15, Issue 2, 2016, Pages 9-13
Author
Esraa H. Humadi
Abstract
Background; Developmental dysplasia of the hip (DDH) means femoral head subluxation or dislocation and/or acetabular dysplasia. Management of neglected (DDH) in children after the walking age is challenging to the Back ground: During pregnancy hyperhomocysteinemia, can cause damage to the vascular system that support the placental function , and this damage might lead to miscarriage and other adverse pregnancy outcome. Objective: To investigate whether lowering homocysteine level in women with recurrent pregnancy loss and hyperhomocysteinemia can improve pregnancy outcome Patients and Method; this study ,initially include 80 women with history of three or more consecutive miscarriage between 8-20 weeks gestation Those with homocystein level >12μmol/l were include in this study (65women) ,they received folic acid 5mg per oral daily ,vitamin B6 40 mg per oral daily , vitamin B12 1000 μg per oral daily for two 2-3 months . After normalization of homocysteine 55 women completed the treatment course and same treatment was continued during pregnancy, 48 women get pregnancy and involved in this study .All participants were followed during pregnancy for any complications that might develop. Result: out of 80 women 48 women participated in this study, their age ranged from 18-42 years.Pregnancy outcome (alive birth) was significantly improved after normalization of homocysteine level and P value is 0.001. Despite that high incidence of complications still developed the most significantly frequent complications include : 16 patients delivered small for gestational age , 14 pregnancies complicated by pregnancy induced hypertension and preeclampsia, ,8 pregnancies ended with preterm labor ,placental abruption complicated around 6 pregnancies and no congenital abnormality neither still birth were reported in this study. Conclusion: Lowering homocysteine level would significantly improve pregnancy outcome (alive birth ) in women with recurrent pregnancy loss.
Keywords
Hyperhomocysteinemia; recurrent pregnancy loss; thrombophilia

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