spectrophotometric Determination of zinc in pharmaceutical  preparations by using a new synthesized reagent [4,5-diphenyl-2-((1E)-(4-(1-(2-phenylhydrazono)ethyl)phenyl)diazenyl)-4H-imidazole]

. F. MOHAMMED Ugd Thil Lpl, ALI

	spectrophotometric Determination of zinc in pharmaceutical preparations by using a new synthesized reagent [4,5-diphenyl-2-((1E)-(4-(1-(2-phenylhydrazono)ethyl)phenyl)diazenyl)-4H-imidazole]
Iraqi National Journal Of Chemistry
Article 1, Volume 15, Issue 3, 2015, Pages 271-283
Author
ALI . F. MOHAMMED ugd thil lpl
Abstract
A simple , rapid, sensitive and new spectrophotometric method to estimate zinc in pharmaceutical preparations is described. The method depends on the reaction between zinc and the new synthesized reagent [4,5-diphenyl-2-((1E)-(4-(1-(2henylhydrazono)ethyl)phenyl)diazenyl)-4H-imidazole] (DPHEDPI ) to form a reddish-pink complex at pH 7.5 with a mole ratio (M:L)of (1:2), the complex exhibits a maximum absorbance at 520 nm with molar absorptivity coefficient (Ɛ) of 4.410 2 L.mol-1 cm-1. Beer’s law is obeyed in the range of (0.5–27) ppm for zinc with correlation coefficient of (0.9996) ,and the stability constant was found to be 110 12L.mol -1 . The relative standard deviation for seven replicate measurements, relative error and recovery values of this method were found to be 0.0015 % , -0.778%, and 99.22% respectively. Finally, this proposed method was applied for the determination of zinc in the zinc sulphate capsules drug and the results were compared with atomic absorption method.
Keywords
diphenyl; phenylhydrazono; imidazole; Zinc

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