Comparative study for effect warm aqueous extract of Zingiben officinale Plant root and voltaren drug on blood parameter and cartilage histological in the white rats males that Induced Rheumatoid Arthritis

	Comparative study for effect warm aqueous extract of Zingiben officinale Plant root and voltaren drug on blood parameter and cartilage histological in the white rats males that Induced Rheumatoid Arthritis
journal of kerbala university
Article 1, Volume 12, Issue 0, 2016, Pages 166-178 PDF (0 K)
Abstract
This study aimed to evaluate effect of the hot aqueous extract of ginger Zingiber officinale plant and Compare with voltaren drug to reduce the impact of Rheumatoid arthritis that induced in white rat males by studying some changes in blood parameters and cartilage histological changes in ankle joint. Used 75 male rats were divided into five groups.First group was served as negative controls( G1). Rats in the second , third , fourth and fifth groups were subcutaneously injected with 0.1 ml of complete Freund's adjuvant for induced rheumatoid arthritis lesion, after that, second group served as positive group (G2), third group intubated after14 days of induced rheumatoid arthritis with 1.8 mg/200 gm B.W voltaren (G3) , fourth group intubated after 14 days of induced rheumatoid arthritis with 9mg/kg B.W. of hot aqueous extraction of ginger root (G4) , last group intubated after 14 days of induced rheumatoid arthritis both ( 1.8mg/200mg B.W and 9mg/kg B.W) and served as fifth group (G5). samples were collected and measuring foot thickness at zero , 14 days and 44 days of experiments and measuring some parameters such as platelets and WBC counts also continuation histological changes for ankle joint cartilage. the results showed : • significant increase (P <0.05) in the number of white blood cells W.B.C and the number of platelets counts in positive group (G2) compared with negative control group, and a significant decrease (P <0.05) in the number of WBC and platelets counts in G3 and G4 and G5 group compared to positive control group G2 • significant increase (P <0.05) in the right foot thickness in positive group (G2) compared with negative control group. And a significant decrease (P <0.05) in the right foot thickness treatment G3 and G4 and G5 as compared to the positive control G2. • The results also Showed Histological section to present histological changes in the ankle joint cartilage of positive group G2 compared with a negative control .that characterized by a necrosis chondrocyte, atrophy , degeneration and decay of some chondrocyte ,when treated with a drug voltaren G3 the necrosis occurrence in some chondrocyte with shrink age chondrocyte nucleus and its location in one side in other as well as the decay occurrence in Collagen fibers, as noted when the hot aqueous extract treatment plant ginger (G4) having some chondrocytes closest were to normal with the presence of some necrotic cells and observed when treated with a drug voltaren and hot aqueous extract treatment plant ginger(G5) necrotic cell in some cells and normal cells.

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