Evaluation Study of Patients Infected with Chronic Hepatitis C in Iraq

C.A.B.M,; H. Muhsun M.B.Ch.B, Laith; F.I.C.M.S,; J. Al-Akayshi C.A.B.M, Ragad; A. Mhawes M.B.Ch.B, Ali

	Evaluation Study of Patients Infected with Chronic Hepatitis C in Iraq
Al-Kindy College Medical Journal
Article 1, Volume 11, Issue 2, 2015, Pages 35-38
Authors
; Laith H. Muhsun M.B.Ch.B; ; Ragad J. Al-Akayshi C.A.B.M; Ali A. Mhawes M.B.Ch.B
Abstract
Background: ;Hepatitis C virus (HCV) is a major cause of chronic liver disease. Approximately 85% of patients acutely infected with HCV progress to chronic liver disease with persistence of HCV-RNA for more than 6 months Among patients with chronic HCV infection , 15-20% progress to end-stage liver disease main transmission methods of the virus is by : blood and blood products ; sharing needles and acupuncture . Objective: To evaluate Iraqi patients infected with chronic HCV, including their treatment, and factors that affect their response to treatment . Methods :This study was performed at Gastroenterology and Hepatology hospital in Baghdad from January 2011 to March 2012.The study enrolled 90 patients with HCV Antibody positive (Ab +ve) , every patient subjected to thorough history taking and clinical examination, and complete investigations , some of the patients subjected to liver biopsy which is analyzed by Ishak classification , the data analyzed by chi square and P value <0.05 considered statistically significant..All these patients were treated with peg interferon alpha2a given once weekly and ribavirin given in two doses daily and follow up the patients during treatment regimen. Results: Ninety patients were enrolled, 66(73.3%) patients were male,24(26.7%) patients were female, patient age range from 18-63,mean age 41.4 year .The predominant genotype is genotype 1:45 (50%) patients , genotype 4:33(36.7%) patients .Only 27(30%)patients have viral load more than 600,000Uml while 63(70%) Patients have viral load less than 600,000Uml .34(37.7%) patients showed End treatment virological response.39 (42.2%) patients had been subjected to liver biopsy including those genotype 1 and4.There was a significant association between viral load and liver enzymes . Conclusion: There is a relatively low complete response to the treatment regimen for hepatitis C . Most of our patient with hepatitis C are discovered accidently, Most of them are male , young or middle age , asymptomatic or have minimal symptom , have low viral load .The commonest genotype is 1(50%) followed by genotype 4(36.7%) .Early virologic response were seen in most of the patients while end treatment response were seen in only 37.78% .
Keywords
hepatitis; Liver; ribavirin

Statistics Article View: 115 PDF Download: 52