Assessment of RBCs membrane protective activity of citicoline and eicosapentanoic- decosahexanoic acid in osmotic fragility model

Abd-Al Wahhab, Iman; Nory Gany, Sarmad; Abdul Kadhim, Hussein

	Assessment of RBCs membrane protective activity of citicoline and eicosapentanoic- decosahexanoic acid in osmotic fragility model
Al-Qadisiah Medical Journal
Article 1, Volume 10, Issue 2, 2014, Pages 118-121 PDF (0 K)
Authors
Iman Abd-Al Wahhab; Sarmad Nory Gany; Hussein Abdul Kadhim
Abstract
Different organic compounds possess a good membranes stabilizing effects that protect cells like erythrocytes from strains exerted by change in medium osmolarity . These changes in tonicity could predispose RBCs for hemolysis . This disorder could be assessed by osmotic fragility test . From those compounds that widen osmotic fragility test values are citicoline (membrane phospholipids precursor) and polyunsaturated fatty acids EPA-DHA. Assessment of these compounds on osmotic fragility test revealed that both of citicoline and EPA-DHA will protect RBCs from hemolysis for a wider range than values of the control blank. Although these effects were statistically not significant on considering statistical correlation test, however, the differences were important on considering t test for the range of saline concentration between 0.4-0.5 at P<0.05 . From the overall results, both citicoline and pufa induced a significant change in statbility of RBCs membrane upon exposure of osmotic effects in the saline concentration between 0.4-0.5. Further evaluation of citicoline and EPA- DHA effects may be necessary before recommending the use these compounds in protection against hemolytic diseases.
Keywords
osmotic fragility test; citicoline; EPA; DHA; hemolytic Anemia

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