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Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 24, Issue 2, 2015, Pages 61-71 | ||
| Author | ||
| Yehia I.Khalil | ||
| Abstract | ||
| An oral bi layer sustained release (SR) strips of Sodium Montelukast SMLT , which is selective leukotriene antagonist , used for patients suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar gum , carrageenan , and xanthan gum , by solvent casting method . The results obtained by this study revealed ,that best fast dissolving film of SMLT was loaded in carrageenan polymer 57% ww (30mg.) , with acceptable physical properties, like film thickness , elastic endurance and surface pH . Besides to that , the disintegration time , and cumulative 80% drug release were estimated 22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 ) as a second layer , appear to be the most promised layer of SMLT loaded in 50 % ww (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH . Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release was 15 minutes extended for 4hours of 100% drug release . Meanwhile , the investigation of possible interference between the drug , and, polymers used revealed no evidence of this effect ,using FTIR , and SEM technique . In an attempt to evaluate the extended release effect of the selected formula , Singulair® plain tablet as a marketed product was used , the result gave more than 4 hours of selected formula , compared with 30 minutes to marketed product Singulair® . The overall results candidates the selected FSR6-7 formula as a promised bi layer buccal fast , as compliance and extended therapy for asthmatic mid- night patients. | ||
| Keywords | ||
| Montelukast sodium; Dual buccal strips; Guar gum; Xanthan gum; Carrageenan | ||
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