Correlation between infiltrated  cytotoxic T-Lymphocyte CD8+ and general T-Lymphocyte CD3+ in some Iraqi patients with bladder carcinoma by using immunohistochemical assay

Al-Huda Ali A. H. Saeed, Noor

	Correlation between infiltrated cytotoxic T-Lymphocyte CD8+ and general T-Lymphocyte CD3+ in some Iraqi patients with bladder carcinoma by using immunohistochemical assay
Al-Mustansiriyah Journal of Science
Article 1, Volume 27, Issue 1, 2016, Pages 39-42
Author
Noor Al-Huda Ali A. H. Saeed
Abstract
The current study was designed to characterized the correlation between the two lymphocytes CD3+ and CD8+ in urinary bladder carcinoma patients and to investigate these to markers in relation with some aspects like age, gender, grade, stage, smoking and sites, of those patients. The expression of correlation between CD3, CD8 and bladder cancer was determined by using immunohistochemical assay. The present results revealed that bladder tissue sections were collected from 40 patients with transitional cell carcinoma and squamous cell carcinoma who had undergone cystactomy . These samples were collected during the period between (2012-2014). Lymphocytes marker CD8 was detected immunohistochemically in 15 patients (37.5%) out of 40. Whereas , the CD3 was detected in 21 (52.5%) out of 40. So, the histological grade included 21, 9, 10 as well, moderate and poor differentiated respectively. Otherwise, results indicated that the positive results for cytotoxic T-lymphocyte CD8 was highly significant related with each of grade, site and stage of the tumor and with significant relationship with each of sex, age and smoking patients . Whereas, the positive results of CD3 lymphocytes was significantly higher related in each of smoking patients and the stage of the tumor, and significantly related with age, site and histological grade but there was non significant correlation with gender of those patients.

Statistics Article View: 186 PDF Download: 16