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Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents | ||
| Baghdad Science Journal | ||
| Article 1, Volume 13, Issue 3, 2016, Pages 568-577 | ||
| Author | ||
| Ali K. Alywee Al-Naseeri | ||
| Abstract | ||
| In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria. | ||
| Keywords | ||
| chalcones; Pyrazolines; Isoxazolines; antibacterial | ||
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