S. Karieb, S. (2016). The Synergistic Effect of Zinc, Coumestrol, Genestein and Daidzein on Proinflammatory Cytokines Production and Receptor Activator of NFκB Ligand Expression that Implicates in Bone Resorption. , 29(2), 13-22.
Sahar S. Karieb. "The Synergistic Effect of Zinc, Coumestrol, Genestein and Daidzein on Proinflammatory Cytokines Production and Receptor Activator of NFκB Ligand Expression that Implicates in Bone Resorption". , 29, 2, 2016, 13-22.
S. Karieb, S. (2016). 'The Synergistic Effect of Zinc, Coumestrol, Genestein and Daidzein on Proinflammatory Cytokines Production and Receptor Activator of NFκB Ligand Expression that Implicates in Bone Resorption', , 29(2), pp. 13-22.
S. Karieb, S. The Synergistic Effect of Zinc, Coumestrol, Genestein and Daidzein on Proinflammatory Cytokines Production and Receptor Activator of NFκB Ligand Expression that Implicates in Bone Resorption. , 2016; 29(2): 13-22.

The Synergistic Effect of Zinc, Coumestrol, Genestein and Daidzein on Proinflammatory Cytokines Production and Receptor Activator of NFκB Ligand Expression that Implicates in Bone Resorption

Ibn Al-Haitham Journal For Pure And Applied Science
Article 1, Volume 29, Issue 2, 2016, Pages 13-22
Author
Sahar S. Karieb
Abstract
Several observations have showed the synergistic effect of nutrients elements and
phytoestrogens on bone resorption elimination. Zn is one of the trace elements found to
increase the stimulatory effect of phytoestrogens including genestein, coumestrol and daidzein
on bone formation; however the synergistic modulation of Zn, genestein, coumestrol and
daidzein on proinflammatory-producing T-cells and receptor activator of NFκB ligand
(RANKL) expression that implicated in osteoclast formation is still open area to debate. This
study found that Zn enhanced the inhibitory effect of genistein, daidzein and coumestrol on
TNF-α expression; however the same effect was shown with daidzein on IL-1β expression
while there is no further effect found with other compounds. Zn is only in combination with
genistein decreaseIL-6 expression; moreover Zn had additional effect on the inhibitory effect
of all test phytoestrogens on RANKL expression in dose-dependent manner. In conclusion,
Zn alone or in combination with phytoestrogens has an inhibitory effect on the expression of
pro-inflammatory cytokines and RANKL that play an important role in the promotion of bone
resorption
Keywords
Zinc; Phytoestrogens; T cells; Pro; inflammatory cytokines
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