The effects of aspirin and fenugreek seed on the testes of white mice

H. Gassim, Musheer; M. Qasim, Hadeel; K. Chaloob, Amal

	The effects of aspirin and fenugreek seed on the testes of white mice
Journal of the Faculty of Medicine
Article 1, Volume 52, Issue 3, 2010, Pages 347-349
Authors
Musheer H. Gassim; Hadeel M. Qasim; Amal K. Chaloob
Abstract
Background: Fenugreek seeds are used as food ingredient in traditional medicines; also aspirin is an incredible chemical with many useful benefits in the medical field. The objective was to study the effect of aspirin and fenugreek on testes of mice. Method: 20 white male mice weighing (18-23gm) were divided into four groups 5 each. Group 1, represented control, group 2, mice treated with fenugreek seed (100mg/KgB.W), group 3 mice treated with aspirin (10mg/Kg B.W), group 4 mice treated with aspirin and fenugreek seed for 21 days. Body weight and testes weights were recorded. Histopathological examination of testes was carried out. Results: a significant decrease (P<0.05) in body weight of mice treated with aspirin when compared to the other groups. A significant decrease (P<0.001) in testicular weight of mice treated with aspirin as compared to control and other groups was noted. Structural changes in testes have shown that: aspirin administration caused a decrease in seminiferous tubules diameter associated with increase in connective tissue between them and basement membrane thickness of seminiferous tubules. While fenugreek seed reverse these changes.Conclusion: fenugreek seeds exhibited antioxidant property that could ameliorate the alternations induced in mice treated with aspirin. Further studies are needed to be done on mammals to support our findings.
Keywords
Aspirin; fenugreek; testes mice

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