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The Role of Cystatin C and Galectin-3 in Cardiorenal Syndrome | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 20, Issue 4, 2015, Pages 60-66 | ||
| Authors | ||
| Nazar Ahemd Naji; Nagham Qasim Kazim | ||
| Abstract | ||
| The growing breadth of studies has shown the implications of combining multiple biomarkers to better chart outcomes between heart and kidneys, and produce desirable results in such patients, as cystatin C and galectin-3 The aim: To estimate the levels of cystatin C and galectin-3, and their relationship with cardiorenal syndrome. Methods: Cystatin C and galectin-3 were obtained from 144 samples: 50 sample with cardiorenal syndrome, 25 sample with heart disease, 25 sample with kidney disease and 44 normal healthy . Results: A highly significant increase (p<0.0001) in the levels of cystatin C in serum of patients with cardirenal syndrome, heart disease and kidney disease compared with normal individuals. A highly significant (p<0.0001) increase in the serum levels of galectin-3 in patients with cardirenal syndrome and patients with heart disease, significant increase in the serum levels of galectin-3 and in patients with kidney disease when compared with control group Conclusions: Cystatin C and galectin-3 have higher diagnostic validity values in the current study, which may be useful as a diagnostic tool to identify recurrence of the cardiorenal syndromes. | ||
| Keywords | ||
| Cardiorenal biomarkers; Cystatin C; galectin | ||
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