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Low expression of PTEN gene is an important trigger event for progression of breast carcinoma | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 7, Issue 3, 2015, Pages 205-214 | ||
| Authors | ||
| Hussein. A. Al-hamadawi; ad. A. Al-Janabi; Thekra A Al-Kashwan; Adnan.w. Al-bider | ||
| Abstract | ||
| PTEN tumor suppressor gene is located on chromosome 10q23, consisting of 9 exons, that encodes a 403 amino acids dual-specificity phosphatase with lipids and protein phosphatase activities. PTEN plays a major role in control multiple cellular functions such as cell metabolism, cell cycle progression and cell survival. The PTEN gene is frequently mutated or inactivated in high proportion of human cancer including breast cancer. The aim of this study was to find the correlation between the decrease of PTEN expression with clinicopathological parameters in breast cancer patients. The current study included 85 sample of Paraffin-embedded breast cancer tissues were analyzed for PTEN expression by immunohistochemistry. We also demonstrated correlation PTEN expression and clinicopathological factors. The loss expression of PTEN protein was found in 50 (58.8%) of 85 breast cancer tumors, while PTEN protein expression was normal in 35 (41.2%) of 85 tumors. The loss expression of PTEN was correlation with lymph node involvement and age patient, and there was no significant correlation with stage, grade, tumor sizes and histological types. Conclusion : These results demonstrated the loss of PTEN expression was found in more than half of breast cancer cases and the reduced expression of PTEN protein was correlated with lymph node metastases and may play a role in progression of breast carcinoma , and hence , worse prognosis in the patients with breast cancer. Beside, the detection of the loss of PTEN expression may serve as a useful biologic marker for progression in invasive breast cancer. | ||
| Keywords | ||
| PTEN tumor suppressor gene breast cancer; PTEN | ||
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