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Synthesis and Characterization of New heterocycles compounds derived from coumarin | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 27, Issue 3, 2016, Pages 29-35 | ||
| Author | ||
| Hiba H. Ibraheem | ||
| Abstract | ||
| 7-hydroxy-4-methylcoumarin was synthesized by the reaction of resorcinol with ethyl acetoacetate, then reacted with chloroacetone and acetic anhydride to give 4-methyl-7-(2- oxopropoxy)-2H-chromen-2-one and 7- Acetoxy -4-methyl-coumarin. New derivatives of chalcone were synthesized by the reaction of 4-methyl-7-(2- oxopropoxy)-2H-chromen-2-one and 7- Acetoxy -4-methyl-coumarin with substituted benzaldehyde in presence of potassium hydroxide. Acid hydrazide synthesis from reaction of ethyl cyanoacetate with hydrazine hydrate also acid hydrazide was reacted with compound 4-methyl-7-(2-oxopropoxy)-2Hchromen- 2-one to give compound (11), then compound (11) reacted with salicylaldehyde and 5-bromosalicylaldehyde to obtain coumarin derivatives (12-13). The new compounds were characterized by some spectroscopic methods (FT-IR spectroscopy, 1H-NMR spectral and GC-Mass) and determination of their physical properties such as melting points. | ||
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