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Study Some Immunological Parameters in Rabbits Immunized with Cryptococcus neoformans | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 56, Issue 4, 2015, Pages 3083-3087 | ||
| Authors | ||
| Ikram A. A. Al-Samarraae; Zainab A. A. Al-Haddad; Alaa K. M. AL-Salmany | ||
| Abstract | ||
| The aims of this study were to prepare Cryptococcus neoformans killed whole cell antigen and evaluate their effects by using DTH- skin test and the differential white blood cells in local rabbits. Fourteen animals of both sexes were divided randomly into two groups. The first group (7 animals) was immunized with 1 ml of Cryptococcus neoformans killed whole cell antigen (1x 10 cells/ml), subcutaneously. A booster dose was given after 14 days of the first dose. The second group (7 animals) was considered as control group. Based on results of DTH-skin test, no significant differences (P< 0.05) were recorded between the concentrations, 15 mg/ml and 7.5 mg/ml after 24, 48 and 72 hrs., but there was a significant differences (P<0.05) between these concentrations and 7.5 mg/ml and 3.75 mg/ml and control site. There was no significant difference between all types of cells (neutrophils, lymphocytes, monocytes, and eosinophils) of immunized and control groups. | ||
| Keywords | ||
| Cryptococcus neoformans; Local rabbit; Immune Response; Experimental infection | ||
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