The effect of Punica granatum nanoparticles in phagocytic cells in patients with Multiple Myeloma

Sakhi Jabir, Majid; Jihad Taqi, Zainab; Ismael Jabbar, Imman; Shammel Ali, Mohammed; Abd-Alsattar, Shimma; Adil Ali, Mayssa

doi:10.30684/etj.2015.117445

	The effect of Punica granatum nanoparticles in phagocytic cells in patients with Multiple Myeloma
Engineering and Technology Journal
Article 1, Volume 33, 9B, 2015, Pages 1702-1711 PDF (545.7 K)
DOI: 10.30684/etj.2015.117445
Authors
Majid Sakhi Jabir; Zainab Jihad Taqi; Imman Ismael Jabbar; Mohammed Shammel Ali; Shimma Abd-Alsattar; Mayssa Adil Ali
Abstract
Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Plasma cells help you fight infections by making antibodies that recognize and attack germs. This study aimed to investigate effect of aqueous extract and silver nanoparticles from Punica granatum peel on the ability of phagocytic cells in patients with Multiple myeloma. Chemical components of Punica granatum were investigated. It was found that they contained most of chemical compounds such as Glycosides, Flavonoids, Alkaloids, Saponins, Tanins, Resins, Terpenes, and Steroids. Our results showed the presence of a significant decrease (p˂0.001) in ability of phagocytic cells in patients, when the results were compared to the control group which included healthy individuals. While, the results showed increase in the percentage of phagocytic cells after added Punica granatum peel silver nanoparticles by increases activity of NADPH enzyme. This increase indicates that the Punica granatum peel silver nanoparticles contain chemical components which act as immune modulators by increase of the percentage of phagocytic cells to engulf bacteria.
Keywords
Peel extract; nanoparticles; Silver nitrate; Phagocytic cells; Multiple myeloma

Statistics Article View: 374 PDF Download: 235