Lipid Profile and Antihypertensive Drugs

A. Abdul-Khader, Abdul-Khader

	Lipid Profile and Antihypertensive Drugs
Al-Kindy College Medical Journal
Article 1, Volume 5, Issue 1, 2009, Pages 1-4
Author
Abdul-Khader A. Abdul-Khader
Abstract
Background: Hypertension and dyslipidemia are cardiovascular risk factors that commonly coexist . Objective : To evaluate the effects of ß - blocker (Atenolol) , ACE inhibitor (Captopril) calcium Channel blocker (Nefidipin ) and diuretics on serum lipid profiles . Method: Thirty untreated hypertensive and 147 hypertensive patient treated with these antihypertensive drugs, attending different public health clinics in Basrah pronivce were enrolled in this study . Serum lipid profile were determined enzymaticaly using kits from BioMerieux, France . Result : The study has revealed that ß-blocker do not significantly affect total cholesterol ( TC ) and LDL- cholesterol , but increase significantly triglyceride (TG) and VLDL – cholesterol and decrease HDL – cholesterol. Diuretics causes a significant elevation of TG with generally no significant changes in TC , LDL – cholesterol , VLDL – cholesterol and HDL-cholesterol. ACE inhibitor and calcium channel blockers appears to have no significant effect on plasma lipids . Conclusion :It may important to measure blood lipid levels to identify pre-existing hyperlipidemia before starting the antihypertensive therapy and to select antihypertensive agent that will not influence the lipid profile or interfere with the therapy of hyperlipidemia
Keywords
Hypertension; lipid and lipid profiles; Antihypertensive; drugs

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