T. A. Al-Sultani, K., M. H. Al-Majidi, S., H. R. Al-Jeilawi, O. (2016). Synthesis, Identification and Evaluation Biological Activity for Some New Triazole, Triazoline and Tetrazoline Derivatives From 2-Mercapto-3-phenyl-4(3H)Quinazolinone. , 57(1), 295-308.
Khitam T. A. Al-Sultani; Suaad M. H. Al-Majidi; Oday H. R. Al-Jeilawi. "Synthesis, Identification and Evaluation Biological Activity for Some New Triazole, Triazoline and Tetrazoline Derivatives From 2-Mercapto-3-phenyl-4(3H)Quinazolinone". , 57, 1, 2016, 295-308.
T. A. Al-Sultani, K., M. H. Al-Majidi, S., H. R. Al-Jeilawi, O. (2016). 'Synthesis, Identification and Evaluation Biological Activity for Some New Triazole, Triazoline and Tetrazoline Derivatives From 2-Mercapto-3-phenyl-4(3H)Quinazolinone', , 57(1), pp. 295-308.
T. A. Al-Sultani, K., M. H. Al-Majidi, S., H. R. Al-Jeilawi, O. Synthesis, Identification and Evaluation Biological Activity for Some New Triazole, Triazoline and Tetrazoline Derivatives From 2-Mercapto-3-phenyl-4(3H)Quinazolinone. , 2016; 57(1): 295-308.

Synthesis, Identification and Evaluation Biological Activity for Some New Triazole, Triazoline and Tetrazoline Derivatives From 2-Mercapto-3-phenyl-4(3H)Quinazolinone

Iraqi Journal of Science
Article 1, Volume 57, Issue 1, 2016, Pages 295-308
Authors
Khitam T. A. Al-Sultani; Suaad M. H. Al-Majidi; Oday H. R. Al-Jeilawi
Abstract
This research, involved synthesis of some new 1,2,3-triazoline and 1,2,3,4-tetrazole derivatives from antharanilic acid as starting material .The first step includes formation of 2-Mercapto-3-phenyl-4(3H)Quinazolinone (0) through reacted of anthranilic acid with phenylisothiocyanate in ethanol, then compound (0) reaction with chloro acetyl chloride in dimethyl foramamide (DMF) to prepare intermediate S-(α-chloroaceto-2-yl)-3-phenylquinazolin-4(3H)-one (1); compound (1) reacted with sodium azide to yield S-(α-azidoaceto-2-yl)-3-phenylquinazolin-4(3H)-one (2), while Schiff bases (3-10) were prepared from condensation of substituted primary aromatic amines with different aromatic aldehydes in absolute ethanol as a solvent. Compound (2) reacted with Schiff bases to give 1,2,3,4-tetrazoline derivatives (11-18) which was entered in 1,3-dipolar cyclo addition reactions with some of α,β-unsaturated carbonyl compounds to give 1,2,3-triazoline (19-24) and triazole (25-27) derivatives respectively. The structure of newly synthesized compounds were identified by spectral methods their [Fourier transform infrared (FTIR) and some of them 1H-NMR, 13C-NMR] and measurements some of its physical properties and some specific reactions. Furthermore were studied the effects of the preparing compounds on some strains of bacteria
Keywords
Quinazolinone; Schiff Base; Trizoline; Tetrazoline; Antimicrobial
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