Kadhim Mohammed, A., Hamid Abdullah, B. (2016). A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions. , 28(1), 78-83.
Alyaa Kadhim Mohammed; Bashar Hamid Abdullah. "A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions". , 28, 1, 2016, 78-83.
Kadhim Mohammed, A., Hamid Abdullah, B. (2016). 'A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions', , 28(1), pp. 78-83.
Kadhim Mohammed, A., Hamid Abdullah, B. A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions. , 2016; 28(1): 78-83.

A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions

Journal of baghdad college of dentistry
Article 1, Volume 28, Issue 1, 2016, Pages 78-83
Authors
Alyaa Kadhim Mohammed; Bashar Hamid Abdullah
Abstract
Background: Langerhans' cell histiocytosis (LCH) is a group of conditions affecting the reticuloendothelial system. It
includes Letterer-Siwe disease, Hand-Schuller-Christian disease and eosinophilic granuloma and most often presents
in childhood.
Materials and methods: Twenty-five cases of LCH were diagnosed histologically and confirmed by CD1a antibody
and assessed immunohistochemically using anti-RANKL and anti-RANK antibodies to evaluate osteoclastogenic
mechanism.
Results: Regarding jaw cases, there was a significant correlation between CD1a and RANK (P=0.016). While in the
skull, highly significant correlation existed between RANK and RANKL (p=0.001). Among the sites, there was no
statistically significant difference found for each the immunohistochemical markers used.
Conclusion: LCH of jaws and skull bear similar osteoclastogenic mechanism when quantified with RANK and RANKL
immunostaining respectively. With a significant correlation between CD1a and RANK for jaw cases, while in the skull
lesions, there was a high significant correlation between RANK and RANKL.
Keywords
Langerhans cell histiocytosis; receptor activator of nuclear factor kappa; B ligand; RANK; cluster of differentiation; Langerhans cells
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