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The association between Oxidized low - density lipoprotein and high sensitivity C reactive protein in acute coronary syndromes patients | ||
| AL-yarmouk Journall | ||
| Article 1, Volume 8, Issue 1, 2016, Pages 157-166 | ||
| Author | ||
| Abbas Mosad Ajeed | ||
| Abstract | ||
| Background: Acute Coronary Syndromes (ACS) represents a pathological, diagnostic, and risk continuum from unstable angina through myocardial infarction (MI) with or without ST-segment elevation. These three conditions share a very similar pathology, although treatment differs. Elevated markers of inflammation, in particular CRP, are associated with an increased risk of future cardiovascular events in healthy subjects, Increased oxidative stress and the generation of the free oxygen radicals can result in modification of LDL to oxidized LDL that could lead to atherosclerotic. Increased blood levels of oxidized low density lipoprotein (ox-LDL) could play a role in these circumstances. Objective: The aim of this study was To measure circulating levels of oxidized-low-density lipoproteins (ox-LDL) in patients with AMI (Q-MI &Non-Q-MI), unstable angina and controls, and to investigate their correlation with hs-CRP in acute coronary syndromes. Patients and Methods: Ninty (90) cardiac patients were admitted to the coronary care unit, Ibn alnafees Hospital and Al kindy Hospital over the period July 2013 and March 2014 with the clinical diagnosis of acute coronary syndrome their ages range was (25-84) years, healthy control (age,sex,matched) were enrolled in this study. All cardiac patients have routine ECG,cardiac biomarkers measurements especially Troponine I, (CK-MB),serelogical markers (hs-C-RP) and Ox-LDL.10 ml of blood needed for assessment of the above makers. Results: : Ox-LDL and hs-CRP in Patients with Acute Coronary Syndromes (ACS) 90 were found significantly high in patients with ACS as compared to healthy subjects, and also a significant positive correlation was observed between Ox-LDL & hs-CRP in Q-MI but positive related in UA & Non-Q-MI . Conclusion: OxLDLand hs-CRP levels are higher in ACS patients, and a significant positive correlation was observed between Ox-LDL & hs-CRP in Q-MI,Ox-LDL and hs-CRP might be markers of destabilization of ACS . | ||
| Keywords | ||
| acute coronary syndromes; Oxidized; LDL; reactive protein | ||
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