- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Synthesis and Characterization of Novel ProDrug Polymers and Their Controlled Release | ||
| Journal of University of Babylon | ||
| Article 1, Volume 24, Issue 9, 2016, Pages 2527-2543 | ||
| Authors | ||
| Firyal M.A; Saadoon A.A; Faris H.A.M | ||
| Abstract | ||
| Many crosslinked polymers have been prepared through many steps, including the esterification of triethanolamine with maleic anhydride toproduce compound (A1) then the carboxylic acid groups of (1) were converted to amide attachments when they reacted with some drug-NH2, The unsaturated maleamides (A2-A5) were polymerized free radically by using dibenzoyl peroxide as an initiator at 90℃. such as Amoxicillin, 4-Amino antipyrine, Cephalexin, and Procaine drug polymers (A6-A9).All prepared monomers and polymers have been characterized by FTIR and 1H-NMR and UV. Spectroscopies. The swelling percentage is higher than 90%. The rate of hydrolysis of a controlled drug release was studied in different pH values at 37℃, at λmax, 270nm and 220nm in basic and acidic medium. TGA and DSC are recorded; It isappeared that the prepared drug polymers have high thermal properties. | ||
| Keywords | ||
| Poly ester; amide; Prodrug; Drug polymer; Controlled release | ||
|
Statistics Article View: 121 PDF Download: 26 |
||