Homocysteine Related Vitamins in Smoking and Non-Smoking Secondary polycythemia

M. Majeed, Hameed

	Homocysteine Related Vitamins in Smoking and Non-Smoking Secondary polycythemia
Diyala Journal For Pure Science
Article 1, Volume 8, Issue 3, 2012, Pages 444-449
Author
Hameed M. Majeed
Abstract
The amino acid homocysteine is an intermediate in metabolic pathways between the common amino acids methionine and cysteine. The vitamins folate ,and B12 ,and to a lesser extent B6, are needed for its proper functioning .Thus ,low availability of folate ,Bl2,or B 6 can block the path way and lead to a buildup of homocysteine. This study was conducted to determine the levels of homocysteine, lipid peroxidation and vitamins in smokers and non- smokers subjects which they come to the blood bank in orders to eliminates the surplus blood ( secondary polycythemia ). The study population consisted of 40 male patients divided in to two groups; 30 smokers and age matched non- smokers 10 subjects. The mean systolic and diastolic blood pressure values and haematocrit were found to be non-significant . Haemoglobin blood values was found to be significantly(p<0.05) higher for smokers than for non- smokers .Serum Vitamin A Significant decrease(p<0.05)in smokers subjects . Vitamins B12, vitamin E and folate found significantly decrease (p<0.1) in smokers as compared to non-smokers. No significant values in B-carotin vitamin B6 and vitamin C in serum between smokers and non- smokers subjects. There was a significant value(p<0.05) of lipid peroxidation in non smokers than smokers subjects. Serum levels of homocysteine in normal value in both groups .
Keywords
homocysteine; lipid peroxidation; vitamins; polycythemia

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