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Experimental Study For The Effect of Benz (a) anthracene in Some Biochemical Variants and Tissue in Male Domestic Rabbits | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 17, Issue 1, 2017, Pages 154-165 | ||
| Author | ||
| Mowafaq M. Zaidan | ||
| Abstract | ||
| The study included the test of protective role of L-carnitine in reduce the side effects which happened by using Benz(a(anthracene as carcinogenic material by injected male rabbits , and dividing the animals into 4 groups which included : ( C ) control group fed with normal diet only , group( G1 ) treated with 200 mg / kg of L-carnitine daily , group ( G2 ) injected with (5 mg / kg ) of carcinogenic material only , group( G3 ) injected with (5mg /kg) with Benz(a)anthracene and treated with 200 mg / kg of L-carnitine daily. The results showed the effective role of L-carnitine in decreasing the side effects of Benz(a)anthracene the results recorded malondialdehyde concentration (MDA) in 4th group C : (1.016±0.212) G1: (1.296±0.251), G2: (2.754±0.493 ) G3: (1.444±0.324) respectively , the results showed increase significant in (MDA) compared with the control and decrease in levels (MDA) with group treatment carnitine and the results Peroxy nitrite (ONOO) recorded in 4th group C : (43.140±7.478) G1: (42.440±8.353) G2: (62.080±7.817) G3: (49.840±1.117) respectively the results showed increase significant in (MDA) compared with the control and decrease in levels (MDA) with group treatment carnitine , in addition to the testosterone hormone The results showed in 4th group C: (4.32±1.306) G1 : (4.66±0.646) G2 : (2.440±0.433) G3: ( 3.50±0.393) respectively the results showed decrease significant in (MDA) compared with the control and increase in levels (MDA) with group treatment carnitine , The histological sections revealed clearly side effects caused by use Benz(a)anthracene campared with control and which treated L-carnitine This indicate of L-carnitine have aprotective role to decrease the side effects. | ||
| Keywords | ||
| carnitine; Benz; Free Radicals | ||
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