- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Spectrophotometric Determination of Bisacodyl in Pure and Pharmaceutical Preparation via Oxidative Coupling Organic Reaction | ||
| Baghdad Science Journal | ||
| Article 1, Volume 14, Issue 1, 2017, Pages 181-188 | ||
| Authors | ||
| Iqbal S. Mohammed; Khansaa A. Nasser; Amal H. Mhemeed | ||
| Abstract | ||
| A simple, accurate and sensitive spectrophotometric way is used to determine Bisacodyl in pure and pharmaceutical preparations. The proposed method depends on using 2,4-Dinitrophenylhydrazine as chromogenic reagent . The method was based on the oxidative coupling reaction of Bisacodyl with 2,4-Dinitrophenylhydrazine with Sodium periodate in the presence of sodium hydroxide as alkaline media to form red water soluble dye product , that has a maximum absorption at λmax 522nm . Beer ,s law is obeyed in the concentration of (2.00–20.00) μg.ml -1 .The molar absorptivity is (6505) L.mol-1.cm-1,a sandall sensitivity of(0.0555) μg.cm-2), correlation coefficient of (0.9970) , Limitof detection (LOD) (0.0312 μg.ml-1), limit of Quantitation (LOQ) (0. 3125 μg.ml-1) and the relative standard deviation of RSD% (1.6). The method gave a successful determination for Bisacodyl in pharmaceutical preparations and the value of recovery % was better than (100.16%) . | ||
| Keywords | ||
| Bisacodyl drug; Spectrophotometric determination; Pharmaceutical preparation | ||
|
Statistics Article View: 44 PDF Download: 2 |
||