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Antioxidant and Anti-Inflammatory Effect of Fruit Juice of Annona Muricata L (Soursop) During Ischemia Reperfusion Injury in Rats | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 15, Issue 1, 2016, Pages 118-123 PDF (0 K) | ||
| Authors | ||
| Mustafa Taha Mohammed; Sarah Isam Abbas | ||
| Abstract | ||
| ABSTRACT: OBJECTIVE: The study included knowledge The chemical components of the Soursop juice and determine whether Soursop prevents ischemia-reperfusion induced brain injuries in rats. METHODS: The chemical components of the prepared fruit extract were detectedits components of glycosides, proteins....etc and we were Determination of trace element and the estimation of the biochemical parameters: Blood samples were harvested from the rats,. Serum IL-10,Adiponectin and oxidative stress levels of Malondialdehyde ( MDA) and Glutathione ( GSH )were estimated. RESULTS: The results showed that the extract contain : glycosides, proteins, saponins, tannins, various phenolic compounds alkaloids , flavonoids, steroids and vitamine C . The results also showed that there were high concentrations of B, Fe , Zn respectively and low concentrations of Mn, Cu, pb,Cd respectively ,very low concentrations Ni ,Co , Se . The levels of oxidative enzymes and Inflammatory cytokines in group 3 were significantly lower than those in the group 2.Our results suggest that soursop treatment protects the rat brain against ischemia-reperfusion induced brain injuries. CONCLUSION: The present study confirm that the fruit extracts of Soursop (Annona Muricata L.) posses in vivo anti-inflammatory and antioxidant activity because of its content (glycosides , tannins , saponins ,proteins ,various phenolic compounds ,alkaloids , flavonoids, steroids and vitamine C ) | ||
| Keywords | ||
| KEY WORDS; Adiponectin; MDA; GSH; soursop; ischemia | ||
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