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Study therapeutic effect of sweet almond(Prunus amygdalus) suspension on serum glucose level and lipid profile of healthy and experimentally induced diabetic rats | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 16, Issue 1, 2016, Pages 116-129 PDF (0 K) | ||
| Author | ||
| Lubn A. Kafi | ||
| Abstract | ||
| The current study aimed to determine some of positive effect of sweet almond suspension (SAS) in lowering blood glucose and lipid profile of experimentally diabetic male rats , by using aloxan . Thirty adult male rats were randomly divided into eight equal groups as follows, nondiabetic non treated control group (NDNTC) ,diabetic non treated control group (DNTC), diabetic treated groups by using two dose of SAS (1.42 or 2.84 g/Kg B.W) (DT1 and DT2), treated control groups by using two doses mentioned above (TC1 and TC2),the results showed significant decrease in means values of animal body weight in DNTC,DT1,DT2, after one week of experiment , in comparison with NDNTC, while the DT1 and DT2 showed increase in body weight started from the 40 days of treatment compared with DNTC in the same period. Also injection of aloxan in DNTC, DT1and DT2,caused significant increase about 2.5 times mean level of blood glucose after five days of the injection in comparison with NDNTC , after the same period , while treatment with SAS led to significant decrease in mean level of blood glucose after 20,40 and 60 days of treatment in comparison with DNTC in the same period . The results showed that the dose 2.84g/Kg B.W. of SAS led to significant decrease in mean level of blood glucose than 1.42 g/Kg B.W. with 20,40 and 60 days in DT1 and DT2. After five days of aloxan injection there was significant increase in Total Cholesterol (TC),Triglyceride(TG),Low Density Lipoprotein Cholesterol ( LDL-C)and Very Low Density Lipoprotein Cholesterol (VLDL-C) and significant decrease in High Density Lipoprotein Cholesterol (HDL-C) in DNTC ,DT1 and DT2 in comparison with NDNTC in the same period ,while the treatment with SAS in DT1 and DT2 led to significant decrease in TC, TG, and LDL-C and increase in HDL-C after 20,40 and 60 days in comparison with DNTC in the same period. The results showed that the dose 2.84 g/Kg B.W caused significant decrease TC,TG,LDL-C, and an increase in HDL-C more than the dose 1.42 g/ Kg B.W. in 20 ,40 and 60 days of treatment with SAS in DT1and DT2 and there was significant decrease in TC,TG,LDL-C and VLDL-C and an increase in HDL-C in TC1 and TC2 after 60 days of treatment with SAS in comparison with NDNTC in same period . The results showed that the dose 2.84 g/ Kg B.W. caused significant decrease in values of TC,TG,LDL-C and an increase in HDL-C than the dose 1.42 g/ Kg B.W in normal and diabetic groups. In conclusion the result indicate the hypoglycemic and hypolipidemic effect of SAS in normal and diabetic rats. | ||
| Keywords | ||
| sweet almond; diabetes mellitus | ||
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