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Determination of Some Oxidative Stress Parameters and Antioxidants in Sample of Iraqi Beta Thalassemia Major Patients | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 58, Issue 1, 2018, Pages 1-3 | ||
| Authors | ||
| Amna K. Ahmed; Jabbar H. Yenzeel | ||
| Abstract | ||
| Repeated blood transfusion in beta thalassemia major patients may lead to peroxidative tissue injury by secondary iron overload. In the present study, 100 patients(50 male+50 female) with beta thalassemia major patients with age (5-20) years and 60 healthy control were included during their attendance at Abin Al_Baladi hospital in Baghdad. Malondialdehyde ,Superoxide Dismutase and Vitamin E, were measured by using kits.The results showed A highly significant (p<0.01)increase in the levels of Malondialdehyde and Superoxide Dismutase, whereas, significant p(<0.01)decrease in the levels of vitamin-E, This suggest that oxidative stress and reduced antioxidant defense mechanism play an important role in pathogenesis of beta thalassemia major. | ||
| Keywords | ||
| Beta thalassemia major; oxidative stress; Antioxidants | ||
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