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Detection of OXA-23 among Carbapenem Resistant Clinical Isolates of Klebsiella pneumoniae in Hilla. | ||
| Journal of University of Babylon | ||
| Article 1, Volume 25, Issue 2, 2017, Pages 454-435 | ||
| Authors | ||
| Fatima Moeen Abbas; Eman Mohammad Jarallah | ||
| Abstract | ||
| This study aimed to assess the presence of blaOXA-23 in clinical isolates of Klebsiella pneumoniae. During the period from April to August 2011, a total of 801 various clinical samples were collected from different hospitals in Hilla city. One hundred and seventy seven (22%) isolates were diagnosed as Klebsiella spp.,117 isolates belonged to K.pneumoniae . High prevalence of K.pneumoniae was detected in Babylon Teaching Hospital for Maternity and Pediatric with 65 isolates. Regarding clinical samples, highest rate were observed for stool samples 38 (27%) followed by sputum 19 (15%). All 117 K.pneumoniae isolates were primarily screened for - lactams resistance, 91 (78%) showed positive results for beta lactams . β- lactam resistance isolates were underwent antimicrobial susceptibility to 26 antibiotics by Kirby-Bauer disk diffusion methods. High resistance rate was recorded for penicillins (carbenicillin and ampicillin) 99% and 94.5%,respectively .Carbapenem resistance was reported in 17 (18.7%) of K. pneumoniae isolates. The presence of blaOXA-23 gene was checked by Polymerase Chain reaction (PCR) and confirmed in 15 (88.2%) of isolates. | ||
| Keywords | ||
| Klebsiella pneumoniae; carbapenem resistance; OXA; lactamase; Polymerase Chain Reaction | ||
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