Evaluation of the effect of some antibiotics on amoxicillin resistant bacteria isolated from middle ear infection: A comparative study

Of Pharmacy, College; University Corresponding Author, Thi-Qar; Mudhafar Abdul-Rahman MSc In Pharmacology, Abeer

	Evaluation of the effect of some antibiotics on amoxicillin resistant bacteria isolated from middle ear infection: A comparative study
Thi-Qar Medical Journal
Article 1, Volume 11, Issue 1, 2016, Pages 103-112
Authors
College of Pharmacy; Thi-Qar University Corresponding author; Abeer Mudhafar Abdul-Rahman MSc in Pharmacology
Abstract
Background: otitis media is one of the leading causes to loss of hears if left untreated. Its fundamental antibiotic is amoxicillin that is widely exposed to bacterial resistance. Alternatives such as cephalosporins have been become mandatory. Objects: firstly is to define the predominant bacteria that isolated from ear discharges. Secondly and most importantly is to evaluate susceptibility of bacterial isolates to each of amoxicillin, cefotaxime, ceftriaxone, and cefixime. Thirdly is to compare bacterial response to above antibiotics among each other. Methods: this study carried out on fifty nine infected patients with otitis media who consulted physicians at ENT department in Al-Habboubi General Hospital in Nasiriyah city from March 2014 to June 2014. Under aseptic conditions, all bacterial culturing and susceptibility tests were done. Collected data were entered into SPSS 19 and translated as o table and figures. Results: a total of 59 patients with a mean age of 25.53 ± 16.195 years were included in this study. It showed that Pseudomonas aeruginosa was a predominant (42.4%) followed by Staphylococcus aureus (37.3%). The susceptibility of Pseudomonas aeruginosa was the highest (40%) to amoxicillin and cefixime among whole used antibiotics. Staphylococcus aureus was highly sensitive to cefixime by 90.9% but amoxicillin revealed a lowest sensitivity (13.6%). Half of E. coli isolates witnessed sensitivity by both of cefotaxime sodium and cefixime. Enterobacter spp. isolates were completely sensitive (100%) to cefotaxime sodium and ceftriaxone. Lastly Proteus spp. was susceptible by all studied antibiotics. Cefixime was the most effective antimicrobial agent with susceptibility of 61% while amoxicillin had the lowest effectiveness (24%). Conclusion: The need to search new antibiotic became urgent due to prevalence of amoxicillin resistant bacteria.

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