A. Thaker, A., M. Abid, F., S. Farhan, A. (2017). Effect of amygdalin and magnetic water to inhibition of colon cancer induced by 1,2-dimethylhydrazine in rats.. , 9(2), 32-40. doi: 10.37652/juaps.2015.124507
A. A. Thaker; Fadel M. Abid; Ahmad S. Farhan. "Effect of amygdalin and magnetic water to inhibition of colon cancer induced by 1,2-dimethylhydrazine in rats.". , 9, 2, 2017, 32-40. doi: 10.37652/juaps.2015.124507
A. Thaker, A., M. Abid, F., S. Farhan, A. (2017). 'Effect of amygdalin and magnetic water to inhibition of colon cancer induced by 1,2-dimethylhydrazine in rats.', , 9(2), pp. 32-40. doi: 10.37652/juaps.2015.124507
A. Thaker, A., M. Abid, F., S. Farhan, A. Effect of amygdalin and magnetic water to inhibition of colon cancer induced by 1,2-dimethylhydrazine in rats.. , 2017; 9(2): 32-40. doi: 10.37652/juaps.2015.124507

Effect of amygdalin and magnetic water to inhibition of colon cancer induced by 1,2-dimethylhydrazine in rats.

Journal of University of Anbar for Pure Science
Article 8, Volume 9, Issue 2, 2015, Pages 32-40    PDF (798.52 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2015.124507
Authors
A. A. Thaker1; Fadel M. Abid2; Ahmad S. Farhan* 3
1University of Anbar - College of Science
2Ministry of Science and Technology - Department of Materials
3University of Anbar - Histology Branch
Abstract
Objective: The present study was undertaken to investigate the chemopreventive efficacy of amygdalin and magnetic water during the initiation phase of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in a rat model.Methods: Seven groups of ten rats each were selected for the study. Group I animals treated as control. Group II rats received for DMH (20 mg/kg body weight) injections subcutaneously once a week for 16 consecutive weeks and then kept without any treatment till the end of the experimental period. Group III rats received amygdalin (20mg/100mg) daily via Oro-gastric tube. Groups IV was given magnetic water freely. Group V was given DMH+Amg. Group VI was given DMH+M.W. Finally, group VII was given DMH+Amg+M.W. Histological changes in the colon were studied.Results: In the study of light microscope the following results were observed: In DMH group was observed hyperplastic aberrant crypt foci of colorectal mucosa and hyperchromatic nuclei. The larger gland are significantly more pleomorphic and hyperchromatic. A mucinous carcinoma with a wide infiltration of submucosa. While a normal appearance of histological structure of colon in other groups were observed.Conclusion: From these results we can conclude that the treatment 1,2-dimethylhydrazine has a negative effect, and the amygdalin and magnetic water reflects an important role in the inhibition of colon cancer.
References

1. بابکر، منذر. ( 2002 ). أثر الماء الممغنط على الملاریا. رسالة ماجستیر- کلیة العلوم- جامعة السودان للعلوم والتکنولوجیا. السودان.

  1. Bollinger, T. M. (2009). Cancer: Step Outside the Box. (3rd ed.) B. McCoy, New Mexico, U.S.A. p:157-163.
  2. Gado, A. ; Ebeid, B. ; Abdelmohsen, A. and Axon, A. (2013). Colorectal cancer in Egypt is commoner in young people: Is this cause for alarm. Alexandria Journal of Medicine.
  3. Karlsson, P. C. (2005). Biomarkers for colon cancer applications in human and rat studies. Kongl carolinska medico chirurgiska institute. Stockholm.
  4. Perse, M. and Cerar, A. (2011). Morphological and Molecular Alterations in 1,2 Dimethylhydrazine and Azoxymethane Induced Colon Carcinogenesis in Rats. Journal of Biomedicine and Biotechnology. 1-14.
  5. Raafat, B. M. (2013). Maximum chelation therapy rate after application of Di-mercpto succinic acid (DMSA) combined with magnetic treated water (MTW) as drinking water. Int. J. Pharm Bio Sci.  4(1): 443 – 454.
  6. Sanganna B. and Kulkarni. A. (2013). Antioxidant status of fruit peel of Citrus reticulata Essential oil on 1, 2 Dimethyl hydrazine induced rat colon carcinogenesis. Research J. of Pharm. Bio. and Chem. Sci. 4: 340-9.
  7. Sharma, A. Sharma, K. K. (2011) Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver. Ind. J. Clin. Biochem. 26:290-5.
  8. Shirahata, S.; Kabayama, S.; Nakano, M.; Miura, T.; Kusumoto, K.;  Gotoh, M.; Hayashi, H.; Otsubo, K.; Morisawa, S. and Katakura, Y. (1997). Magnetically treated water scavenges active oxygen species and protects DNA from oxidative damage. Biochem. Biophys. Res. Commun. 234(1): 269- 274.
  9. Van Rossen,  M. E. ; Sluiter, W. ;  Bonthuis, F. ; Jeekel, H. ; Marquet, R. L. van Eijck, C. H. (2000).  Scavenging of reactive oxygen species leads to diminished peritoneal tumor recurrence. Cancer Res. 60:5625-9.
  10. Zhou, C. ; Qian, L. ; Ma, H. ; Yu, X. ; Zhang, Y. ; Qu, W. ; Zhang, X.  ; Xia, W. (2012). Enhancement of amygdalin activated with  β-D-glucosidase on HepG2 cells  proliferation and apoptosis. J. Carbohydrate Polymers, vol. 90, , p. 516-523.

 

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